Is depression a mental or physical illness? Unravelling the inflammation hypothesis.

Most people feel down, tired and inactive when they’re injured or ill. This “sickness behaviour” is caused by the activation of the body’s immune response. It’s the brain’s way of conserving energy so the body can heal. This immune response can also occur in people with depression. This has prompted some researchers and clinicians to hypothesise that depression is actually a side effect of the inflammatory process. But while there may be a connection between inflammation and depression, … [Read more...]

Inflammation and Mood

Depression and other mood disorders could be the brain’s response to inflammation, according to a new nationwide study from Denmark released Wednesday. The study, published in the journal JAMA Psychiatry, is the largest of its kind and adds further evidence to the emerging theory that certain mental health conditions could be caused by inflammation. Researchers found that patients with an autoimmune disease were 45 percent more likely to have a mood disorder, while any history of infection … [Read more...]